Molecular biology of cancer-associated fibroblasts: Can these cells be targeted in anti-cancer therapy?

Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy.

Although initially responsive to chemotherapy, many patients with ovarian cancer subsequently develop relapsed and potentially fatal metastatic disease, which is thought to develop from cancer stem cells (CSCs) that are relatively resistant to conventional therapy. Here, we show that CSCs express a type I receptor tyrosine kinase-like orphan receptor (ROR1), which is expressed during embryogene...

Targeted cancer therapy: review article

Cancer is one of the most dangerous health problems of today modern societies which has an increasing rate especially in developing countries. There are many diverse ongoing treatment attempts trying to defeat cancer. Despite that, scientists have been unable to find a permanent cure for this disease. In many cases although there is a successful first response in patients, cancer cells are fina...

Cancer virotherapy: Targeting cancer cells by microRNA mechanism for selective replication of oncolytic viruses in these cells

Cancer, as one of the most serious public health problems, is the second-leading cause of death in the world after cardiovascular disease. The number of patients and the resulting mortality are increasing worldwide; therefore, early diagnosis, prevention, and effective treatment of cancer are very important. Current treatments such as chemotherapy and radiation therapy are often non-selective a...

Targeted Approach in anti cancer therapy

Anti Cancer Drugs Used for Targeted Therapy

A primary goal of targeted therapy is to fight cancer cells with more precision and potentially fewer side effects. For this reason it is a promising therapy for the 3rd millennium1. Traditional cytotoxic chemotherapy works primarily through the inhibition of cell division. In addition to cancer cells, other rapidly dividing cells (e.g. hair, gastrointestinal epithelium, bone marrow) are affect...